Molecular Dosimetry and Human Cancer: Analytical, Epidemiological, and Social ConsiderationsThis book provides readers with a broad view of the field of molecular dosimetry by discussing its origins, underlying concepts, the wide range of approaches to making the measurements and applications for the results. Specific topics include the direct assessment of human carcinogens and assessment of low level risks, molecular epidemiology, validation of molecular epidemiologic methods, quantitative analysis of DNA adducts, the application of fluorescence to analysis of genotoxicity, exposure control versus risk assessment, genetic testing in the workplace, and medical screening for carcinogenesis. |
Contents
Chapter | 3 |
Chapter | 15 |
INTERINDIVIDUAL VARIATION IN BIOTRANSFORMATION | 27 |
Summary and Conclusions | 40 |
ETHICAL ECONOMIC AND LEGAL | 41 |
Conclusion | 69 |
Chapter 5 | 77 |
The Power of a Study | 83 |
Quantitation of DNA Adducts in Biological Samples | 220 |
References | 226 |
cisDiamminedichloroplatinumII | 237 |
Summary | 243 |
Chapter 14 | 249 |
References | 257 |
DETECTION OF ALKYLATED DNA ADDUCTS | 263 |
DNA Alkylation Adducts in Human Tissues | 273 |
Chapter 6 | 89 |
Risk Estimation of Ethene | 96 |
Sensitivity of HemoglobinAdduct Determination | 98 |
Chapter 7 | 105 |
Other Applications | 122 |
DNA Alterations in White Blood Cells of IronFoundry | 144 |
68 | 145 |
Chapter 9 | 151 |
DNA Adducts in Smokers and Nonsmokers | 158 |
Sources of DNA for Monitoring DNAAdduct Formation in Humans | 165 |
Chapter 10 | 171 |
Determination of 23Ethenoguanine after Electrophore Labeling | 178 |
88888 | 186 |
Chapter 11 | 189 |
Hydrolysis of Hemoglobin | 197 |
Background Levels of Modified Amino Acids in Hemoglobin | 204 |
Chapter 12 | 211 |
Characterization of Antisera | 219 |
Chapter 16 | 281 |
Acknowledgments | 294 |
Chapter 17 | 303 |
Aflatoxin and Liver Cancer | 311 |
Summary | 321 |
Overview of Nicotine Metabolism | 331 |
Metabolism of NNK and NNN | 346 |
References | 354 |
Chapter 19 | 363 |
References | 379 |
THE BIOETHICS OF BIOMONITORING PEOPLE | 385 |
References | 398 |
Private Benefits and Public Health Impacts | 404 |
Policy Implications | 412 |
Toward an Ethical Theory for Human Monitoring | 421 |
Positive Uses of Human Monitoring | 439 |
Common terms and phrases
4-aminobiphenyl adduct formation adduct levels adducts in human aflatoxin agents alkylating animals antibody assay Autrup B. F. Trump Bartsch benzo(a)pyrene binding Biochem biological bladder bronchus C. C. Harris Cancer Res Carcinog carcinogenesis carcinogens chemical carcinogens chromatography cigarette smoke compounds cotinine covalent cytochrome P-450 detection determined DNA adducts DNA damage dose Ehrenberg ELISA environmental enzyme epidemiological ethylene oxide explant culture explants exposed F. P. Guengerich fluorescence G. D. Stoner GC-MS genetic genotoxic globin Hemminki hemoglobin HPLC human liver human tissues I-compounds I. K. O'Neill IARC immunoassay individuals laboratory lung lymphocytes M. C. Poirier markers mass spectrometry measured metabolism metabolites methods methylating modified molecular monitoring mutagens Mutat Natl nicotine nitrosamines nitrosation nonsmokers nucleic acids nucleotides Osterman-Golkar P. B. Farmer patients Perera protein quantitative R. M. Santella Randerath rats samples sensitivity specific studies techniques tobacco Törnqvist Toxicol tumor urinary urine vitro vivo white blood cells workers